amiGenomeAI — AI Genomics & Genetics Companion

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Sequencing & Bioinformatics

WGS, RNA-seq, variant calling, pipelines, quality control, and data analysis

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Clinical Genomics

Variant classification, pharmacogenomics, tumor profiling, genetic testing

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Gene Editing

CRISPR-Cas9/12/13, guide RNA design, base editing, prime editing, delivery

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Population Genetics

GWAS, ancestry, selection, admixture, Hardy-Weinberg, linkage disequilibrium

🧬 Variant Analysis
📋 BRCA2 c.5946delT — Classification:
  1. ✅ ClinVar: Pathogenic (reviewed by expert panel)
  2. ⚠️ Frameshift → premature stop codon at p.Ser1982ArgfsTer22
  3. 📊 gnomAD frequency: 0.00004 (extremely rare)
🔬 Next: Confirm with ACMG criteria (PVS1, PM2, PP5)
⚠️ Clinical interpretation requires genetic counselor review

Ask about genomics & genetics

🧬 amiGenomeAI — dual-engine verified genomics advice. 5 free questions/day.
Not a genetic counselor. For clinical results, consult a certified professional.

Free: 5 questions/day | Pro: unlimited

What amiGenomeAI can help with

🔬 Sequencing

WGS, WES, RNA-seq, single-cell, long-read, library prep, QC, coverage

💻 Bioinformatics

BWA, STAR, GATK, DeepVariant, VEP, Nextflow, Snakemake, IGV

💊 Pharmacogenomics

CYP450, DPYD, HLA typing, drug-gene interactions, PharmGKB, CPIC

🏥 Clinical Genomics

ACMG classification, tumor profiling, ctDNA, companion diagnostics

✂️ CRISPR & Editing

Guide design, off-target analysis, base/prime editing, delivery methods

📊 Databases

ClinVar, gnomAD, COSMIC, OMIM, Ensembl, UniProt, PDB, STRING